Quantum Logic Gate Model for G Protein Coupled Receptors

G Protein-coupled receptors

G protein-coupled receptors and heterotrimeric G proteins can diffuse laterally in the plasma membrane such that one receptor can catalyze the activation (GDP/GTP exchange) of multiple G proteins. In some cases, these processes are fast enough to support molecular signal amplification, where a single receptor maintains the activation of multiple G proteins at steady-state. Amplification in cell...

G-protein-coupled receptors.

G-Protein-coupled receptors mediate many of the hypnotic and analgesic actions of the drugs employed in anesthesia. Notably, opioid agonists represent the most successful and efficacious class of analgesic agents employed over the last century. Also, major clinical advances have been made by the study of alpha(2) adrenoceptor agonists, which possess both hypnotic and analgesic qualities that ar...

Modelling G protein-coupled receptors

Lysophospholipid G protein-coupled receptors.

The many biological responses documented for lysophospholipids that include lysophosphatidic acid and sphingosine 1-phosphate can be mechanistically attributed to signaling through specific G protein-coupled receptors. At least nine receptors have now been identified, and the total number is likely to be larger. In this brief review, we note cogent features of lysophospholipid receptors, includ...

G protein-coupled receptors for lysophosphatidylethanolamine

Lysophospholipids like lysophosphatidic acid (LPA) and sphingosine 1-phosphate have been intensively studied over the last several decades, and these studies have resulted in the identification of their G protein-coupled receptors (GPCR) and in the discoveries of new drugs targeting GPCRs. However, lysophosphatidylethanolamine (LPE) has not attracted much research attention. Recently, we found ...